ABL90 Flex Plus

The expansion of POCT at MIM-NRI between 2017 and 2024 highlights the vital role of rapid bedside diagnostics in modern clinical practice. By integrating a high volume of tests with robust quality management systems like AQURE, the hospital has successfully balanced speed with analytical precision. Ultimately, these tools are indispensable for accelerating life-saving treatments and optimizing hospital efficiency in critical care settings.

"The presence of OHCbl in blood clearly interfered with the oximetry measurements of the hemoglobin component fractions by falsely increasing the levels of MetHb and COHb. Blood levels of MetHb and COHb cannot be reliably determined by the co-oximetry when OHCbl is known or suspected."

This study confirms that prehospital blood gas analysis is a highly effective tool for risk stratification. High lactate, low pH, and abnormal CO2 levels are significantly associated with increased 7-day and 30-day mortality, as well as a higher likelihood of requiring ICU admission and mechanical ventilation. These biomarkers allow emergency physicians to identify critically ill patients early and tailor intensive treatments before hospital arrival.

"In conclusion, the Cr testing in serum and H-WB by the ABL90 FLEX PLUS was comparable with that by four automated chemistry analyzers commonly used in clinical laboratories. Therefore, they can be equivalently used in situations where the ABL90 FLEX PLUS is used simultaneously with one or more chemistry analyzers in one institute. However, C-WB is not recommended."

"In this case, we found a surprisingly normal AG acidosis in a patient with severe salicylate poisoning due to incorrect chloride measurements, caused by interference of low bicarbonate and possible a minor impact of the high salicylate concentration. Clinicians should be aware of this phenomenon and consider the possibility of salicylate poisoning in patients presenting with a normal AG acidosis. The patient was treated with intermittent haemodialysis and strict pH management, which lead to a fast recovery. No rebound toxicity was observed after discontinuing haemodialysis."

"This study established reference standards for 10 critical care analytes in the CALIPER cohort for the first time. These data contribute to our understanding of normative pediatric values for venous electrolytes, metabolites, and blood gases on a modern POCT instrument, facilitating test interpretation in clinical settings that use these assays."

"We presented a description of the multi-wavelength time-domain NIRS system that obtains 32 DTOFs at up to 3 Hz. The quantitative results for the three established protocols are consistent with the best performances of the reported systems. The results for measurements on blood-lipid phantoms are close to the reference values obtained with OxiplexTS and co-oximetry, except a discrepancy was found for the lowest concentration of Intralipid. Venous and arterial cuff occlusions on the forearm resulted in the expected hemoglobin changes that are consistent with the physiology of such hemodynamic challenges. The presented quantitative parameters can be compared to other systems that measured similar tests."

This retrospective study of 519 cardiac surgery patients demonstrates that while the Terumo CDI 500 and Spectrum Medical Quantum show high statistical correlation with the ABL90 FLEX benchtop analyzer, they lack the precision required for direct substitution. Although both devices reported hemoglobin values within 1 g/dL of the reference standard in over 86% of cases, the accuracy for venous saturation (SvO2) was considerably lower. Despite the small magnitude of mean differences, the wide 95% Limits of Agreement suggest that these continuous monitoring systems should be utilized strictly as trending tools rather than definitive replacements for laboratory-grade benchtop analysis.

"In conclusion, the Withings ScanWatch is able to measure SpO2 levels with adequate accuracy at a clinical grade. No undesirable effects or adverse events were reported during the study."

"Using the safePICO syringe with automatic mixing at the point of care results in a significantly better correlation of hemoglobin with the standardized method."

"BGA is a more reliable alternative to SBR than TcB, particularly in time-critical or resource-limited settings. While TcB remains a non-invasive screening tool, limited accuracy post-phototherapy and with darker skinned neonates indicate confirmatory SBR testing. These findings support the selective and context-aware use of BGA and TcB to optimise neonatal hyperbilirubinaemia management and reduce interventions."

"Clinically important systematic differences in sO2 measurement exist between GEM and ABL blood analyzers that perform co-oximetry, with potential implications for patient care and pulse oximeter verification studies. Larger studies with more co-oximeter brands, coupled with blood tonometry, are needed to better characterize these findings. In the meantime, regulatory standards and reports of pulse oximeter clinical trials should account for these findings and specify which manufacturer's co-oximeters were used."

"In conclusion, the EG-i30 system demonstrates clinical performance equivalent to the ABL90 FLEX, showing excellent correlation and diagnostic accuracy across all key parameters. With bias levels well within acceptable medical limits, the EG-i30 serves as a reliable, maintenance-free, and cost-effective solution for rapid point-of-care testing in emergency and critical care settings."

"This study effectively translates previous laboratory findings into clinical practice, highlighting the practical utility of PIs to guide the accurate interpretation of bedside ctHb measurements [GEM 4000 and GEM 5000 (Werfen GmbH), ABL90 Flex plus (Radiometer GmbH), HemoCue Hb 201+ (HemoCue), and XN 9000/9100 (Sysmex Deutschland GmbH)]" under acute care conditions."

"In this study, the reliability of RAD [ABL90] was superior to SIE [Rapidpoint 500] at nSL423 and HA4,559. In contrast to RAD, the performance of SIE declined at HA4,559. SIE was more prone to not reporting all variables, especially at HA4559."

"This study established comprehensive pediatric RIs for random glucose (whole blood) on modern POC systems in the CALIPER cohort for the first time. Results demonstrate excellent concordance in glucose values between POC systems and good comparability with a laboratory-based analyzer. These data will assist in more accurate clinical decision-making in pediatric healthcare institutions."

"In severe hypernatremia, sodium results produced by blood gas and plasma analyzers [ABL90, RAPIDPoint 500, and GEM 4000] can differ significantly."

"Acceptable performance characteristics, small sample volume, and rapid TAT make ABL90 Flex Plus an acceptable alternative analyzer for CSF glucose and lactate."

"Based on both our Blood Gas and Chemistry Surveys, we conclude that both brands of analyzers performed within analytically and clinically acceptable limits throughout the year, with no evidence for the type of errors reported previously."

The ABL90 FLEX PLUS demonstrates excellent analytical performance for urea and creatinine, meeting rigorous biological variation standards with high precision and strong correlation to central laboratory assays. Its resistance to common interferences and accuracy at high pre-dialysis levels make it a fast, reliable, and convenient tool for real-time clinical monitoring and dialysis management.